CD62P, P-selectin; granule membrane protein 140; GMP-140; PADGEM; leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P (SELP, GMRP, GRMP)
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Function
- Ca+2-dependent receptor for myeloid cells
- role in trafficking of leukocytes to sites of inflammation & injury.
- binds to carbohydrates on neutrophils & monocytes
- mediates interaction of activated endothelial cells or platelets with leukocytes
- ligand recognized is fucosylated sialyl-Lewis X (CD15) on leukocytes
- mediates neutrophil adhesion & leukocyte rolling on vascular surfaces during the initial steps in inflammation through interaction with PSGL1
- interacts with SNX17
- interacts with PSGL1/SEPL; interaction requires the sialyl-Lewis X epitope & specific Tyr sulfation on PSGL1
- interaction with CD162 ?
Structure
- belongs to the selectin/LECAM family
- contains 1 C-type lectin domain
- contains 1 EGF-like domain
- contains 9 Sushi (CCP/SCR) domains
Compartment
membrane
Expression
- stored in the alpha-granules of platelets & Weibel-Palade bodies of endothelial cells
- upon cell activation by agonists, P-selectin is transported rapidly to the cell surface
- expressed in platelets, megakaryocytes, activated endothelial cells
Pathology
- defects in SELP may be a cause of susceptibility to ischemic stroke
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P16109.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/selp/
- ↑ Functional glycomics gateway - glycan binding: P-selectin http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_354
- ↑ TA, Lasky LA. Cell adhesion. Sticky sugars for selectins. Nature. 1991 Jan 17;349(6306):196-7. No abstract available. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1987472
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002