sialoadhesin; sialic acid-binding Ig-like lectin 1; siglec-1; CD169 (SIGLEC1, SN)

Function

• macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells & CD8 T-cells
• preferentially binds to alpha-2,3-linked sialic acid
• binds to SPN/CD43 on T-cells (putative)
• may play a role in hemopoiesis

Structure

• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 16 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoform 1: cell membrane; single-pass type 1 membrane protein
• isoform 2: secreted

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist

Expression

• expressed by macrophages in various tissues
• high levels are found in spleen, lymph node, perivascular macrophages in brain
• expressed at lower levels in bone marrow, liver Kupffer cells & lamina propria of colon & lung
• expressed by inflammatory macrophages in rheumatoid arthritis

More general terms

• CD antigen
• adhesion receptor
• sialic acid-binding immunoglobulin-like lectin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6614
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6614
• OMIM: https://mirror.omim.org/entry/600751
• UniProt: http://www.uniprot.org/uniprot/Q9BZZ2.html