CD8
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Function
- identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets
- CD8 is thought to play a role in the process of T-cell mediated killing
- signal is transduced by the associated tyrosine kinase lck
- activation results in phospholipase activity (presumably PLC)
Structure
- heterodimer of CD8-alpha & CD8-beta, linked by two disulfide bonds, or
- heterodimer on thymocytes & as homodimer of CD8-alpha on peripheral blood T-lymphocytes
Expression
- mature peripheral T cells ~25-35%
- most cytotoxic T cells
- CD4/CD8+ thymocytes
- NK cells ~30%
- cortical thymocytes ~70-80%
Laboratory
- a marker for cytotoxic T cells, present on 30% of peripheral T cells
More general terms
Additional terms
Components
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- ↑ OMIM https://mirror.omim.org/entry/186730/186910
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Wikipedia; Note: CD8 entry http://en.wikipedia.org/wiki/CD8