CD10 (neprilysin, neutral endopeptidase, enkephalinase, common acute lymphoblastic leukemia antigen, CALLA, atriopeptidase, MME, EPN)

From Aaushi
Jump to navigation Jump to search

Function

Cofactor: binds 1 Zn+2 per subunit

Structure

belongs to the peptidase M13 family

Compartment

Expression

Pathology

More general terms

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
  2. UniProt http://www.uniprot.org/uniprot/Q00973.html
  3. Journal Watch 20(5):38, 2000 Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med. 2000 Feb;6(2):143-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10655101
  4. Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 2001 Oct 25;32(2):177-80. Review. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/11683988
  5. 5.0 5.1 <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  6. 6.0 6.1 Greg Gole, UCLA Sepulveda VA, 02/12/2004, personal communication
  7. 7.0 7.1 7.2 Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci. 2004 Jan 28;24(4):991-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14749444
  8. 8.0 8.1 Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci. 2004;22(1-2):5-11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14742905
  9. 9.0 9.1 Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/MMEID41386ch3q25.html

Database