CD23; low affinity immunoglobulin epsilon Fc receptor; lymphocyte IgE receptor; Fc-epsilon-RII; BLAST-2; immunoglobulin E-binding factor (FCER2, CD23A, FCE2, IGEBF)
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Function
- low affinity IgE Fc receptor
- associates with/activates fyn[2]
- triggers release of monokines by monocytes
- B cell growth factor, promoting differentiation into plasma cells
- regulation of IgE production
Structure
- N- & O-glycosylated
- contains 1 C-type lectin domain
Compartment
- cell membrane
- also exists as a soluble excreted form
Alternative splicing
named isoforms=2
Expression
- activated mature B cells expressing IgM or IgD
- monocytes/macrophages
- subset of T cells
- platelets
- eosinophils
- Langerhans cells
- follicular dendritic cells
Pathology
- expressed in B-cell CLL/SLL
- mantle cell lymphoma stains negatively with antibody
Laboratory
- CD21 & CD23 are dendritic cell markers
More general terms
References
- ↑ Kolb JP et al Monoclonal anti-CD23 antibodies induce a rise in [Ca2+]i and polyphosphoinositide hydrolysis in human activated B cells. Involvement of a Gp protein. J Immunol. 1990 Jul 15;145(2):429-37. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2164062
- ↑ 2.0 2.1 OMIM https://mirror.omim.org/entry/151445
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Functional glycomics gateway - glycan binding - Note: CD23 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_221
- ↑ UniProt http://www.uniprot.org/uniprot/P06734.html