regulator of G-protein signaling 1; RGS1; early response protein 1R20; B-cell activation protein BL34 (RGS1, 1R20, BL34, IER1)

Function

• inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits convertin them to their inactive GDP-bound form
• role in regulation of B-cell activation & proliferation (putative)
• may be phosphorylated
• may be functionally regulated by protein kinase(s)

Structure

contains 1 RGS domain

Alternative splicing

named isoforms=2

Expression

• B-cell specific
• expression is relatively low in B-cells
• induced in response to several B-cell activation signals

Pathology

• expression is low in chronic lymphocytic leukemia B-cells
• expression is consititively high in
  • non-Hodgkin's lymphoma
  • hairy cell leukemia

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08116.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5996
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5996
• OMIM: https://mirror.omim.org/entry/600323