drug interaction(s) of calcium channel blockers with clarithromycin
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Drug interactions
- clarithromycin, a potent inhibitor of cyt P450 3A4 can significantly increase plasma levels of calcium channel blockers
- older patients may end up in hospital with hypotension or shock
- reports of edema, arrythmias or heart block
- combination linked to acute renal failure (RR=2)[2]
More general terms
References
- ↑ Prescriber's Letter 18(3): 2011 COMMENTARY: Calcium Channel Blocker-Macrolide Interaction Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270307&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 2.0 2.1 Gandhi S et al Calcium-channel blocker - Clarithromycin Drug Interactions and Acute Kidney Injury. JAMA. Published online November 09, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24346990 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1769739