QT prolongation
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Introduction
Prolongation of the electrocardiogram QT interval.
Etiology
- pharmaceutical agents (see drug-induced QT prolongation)
- electrolyte disturbances
- endocrine disorders
- intracranial disorders
- nutritional disorders
- liquid protein diet
- starvation
Epidemiology
- women are predisposed to QT prolongation
- the QT interval is generally longer in women than men[3]
Diagnostic procedures
Complications
- QTc prolongation predisposes to torsades de pointes
- QTc prolongation identifies hospitalized patients with increased risk of mortality[4]
Management
- avoid or discontinue pharmaceutical agents that prolong the QT interval
More general terms
More specific terms
Additional terms
References
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 151
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18. American College of Physicians, Philadelphia 1998, 2012, 2015, 2018.
- ↑ 3.0 3.1 Prescriber's Letter 8(4):19 2001
- ↑ 4.0 4.1 Haugaa KH et al. Institution-wide QT alert system identifies patients with a high risk of mortality. Mayo Clin Proc 2013 Apr; 88:315. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23541006
Mizusawa Y and Wilde AAM. QT prolongation and mortality in hospital settings: Identifying patients at high risk. Mayo Clin Proc 2013 Apr; 88:309. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23541004 - ↑ Drew BJ, Ackerman MJ, Funk M et al Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 2010 Mar 2;121(8):1047-60. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20142454
- ↑ 6.0 6.1 Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
- ↑ Trinkley KE, Page RL 2nd, Lien H, Yamanouye K, Tisdale JE. QT interval prolongation and the risk of torsades de pointes: essentials for clinicians. Curr Med Res Opin. 2013 Dec;29(12):1719-26. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24020938