long QT syndrome

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Etiology

Epidemiology

  • uncommon
  • more common in women than in men

Pathology

Genetics

long QT syndrome genotyping*

* referral for electrophysiological testing takes preference to genotyping[2]

Clinical manifestations

Diagnostic procedures

* QTc > 460 msec, > 500 msec[2]

Complications

* risk increased with physical or emotional stress

Management

More general terms

More specific terms

Additional terms

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 125
  2. Jump up to: 2.0 2.1 2.2 2.3 2.4 2.5 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2012, 2015, 2018, 2023.
  3. Jump up to: 3.0 3.1 Hobbs JB et al, Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 2006, 296:1249 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16968849
  4. Goldenberg I, Moss AJ. Long QT syndrome. J Am Coll Cardiol. 2008 Jun 17;51(24):2291-300. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18549912
  5. Jump up to: 5.0 5.1 5.2 Shimizu W, Makimoto H, Yamagata K et al Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients. JAMA Cardiol. Published online February 13, 2019 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30758498 https://jamanetwork.com/journals/jamacardiology/fullarticle/2724694
    Zareba W Sex and Genotype in Long QT Syndrome Risk Stratification. JAMA Cardiol. Published online February 13, 2019 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30758500 https://jamanetwork.com/journals/jamacardiology/fullarticle/2724693
  6. Jump up to: 6.0 6.1 European Society of Cardiology Ventricular Arrhythmia Clinical Practice Guidelines (ESC, 2022) Medscape. Sept 30, 2022 https://reference.medscape.com/viewarticle/981520
    Zeppenfeld K, Tfelt-Hansen J, de Riva M et al 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal, Volume 43, Issue 40, 21 October 2022, Pages 3997-4126 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36017572 https://academic.oup.com/eurheartj/article/43/40/3997/6675633
  7. Roden DM Clinical practice. Long-QT syndrome. N Engl J Med 2008;358:169-76. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18184962 https://www.nejm.org/doi/pdf/10.1056/NEJMcp0706513
  8. Genedis; Note: congenital long QT syndrome website http://www.tau.ac.il/lifesci/bioinfo/genedis/heart/long_qt.html

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