K+ channel subfamily E member 1; K+ voltage-gated channel subfamily E member 1; IKs producing slow voltage-gated K+ channel subunit beta mink; minimal K+ channel; delayed rectifier K+ channel subunit IsK (KCNE1)

Function

• coassembles with voltage-gated K+ channel alpha subunits to modulate gating kinetics
• ancillary protein that assembles as a beta subunit with a voltage-gated K+ channel complex of pore-forming alpha subunits
• modulates the gating kinetics & enhances stability of the channel complex
• assembled with KCNQ1/KVLQT1, forms the slowly activating delayed rectifier cardiac K+ (IKs) channel; the outward current reaches its steady state only after 50 seconds
• assembled with KCNH2/HERG, may modulate the rapidly activating component of the delayed rectifying K+ current in heart (IKr); phosphorylation inhibits the K+ current
• associates with KCNQ1/KVLQT1 & KCNH2/HERG

Structure

belongs to the K+ channel KCNE family

Compartment

membrane; single-pass type 1 membrane protein

Expression

• expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes
• not detected in pancreas, spleen, prostate & colon
• restrictively localized in the apical membrane portion of epithelial cells

Pathology

• defects in KCNE1 are the cause of
  • Jervell & Lange-Nielsen syndrome type 2
  • long QT syndrome type 5;
  • KCNE1 mutants form channels that open slowly & close rapidly, thereby diminishing K+ currents

More general terms

• K+ channel subfamily E
• glycoprotein
• phosphoprotein
• protein subunit

Additional terms

• voltage-gated K+ channel

Database

• UniProt: http://www.uniprot.org/uniprot/P15382.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3753
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3753
• OMIM: https://mirror.omim.org/entry/176261
• OMIM: https://mirror.omim.org/entry/612347