atenolol (Tenormin)

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Introduction

Tradename: Tenormin. A selective beta-1 antagonist.

Indications

Contraindications

pregnancy category = c

safety in lactation = -

Dosage

  • acute MI: 5 mg IV over 5 min, repeat in 10 min.
  • HTN: start 50 mg PO QD, max 200 mg/day.

Tabs: 25, 50, 100 mg.

Caution:

Dosage adjustment in renal failure

Table

glomerular filtration rate dose
> 35 mL/min 50 mg QD
15-35 mL/min 50 mg QD
< 15 mL/min 50 mg QID

Pharmacokinetics

elimination via kidney

protein binding = <5 %

elimination by hemodialysis = +

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990, pg 230
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  4. 4.0 4.1 Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 470
  5. 5.0 5.1 Prescriber's Letter 11(12): 2004 Atenolol and Its Use in Hypertension Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=201215&pb=PRL (subscription needed) http://www.prescribersletter.com
    Journal Watch 24(24):182, 2004 Carlberg B, Samuelsson O, Lindholm LH. Atenolol in hypertension: is it a wise choice? Lancet. 2004 Nov 6;364(9446):1684-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15530629
  6. 6.0 6.1 6.2 6.3 Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  7. 7.0 7.1 7.2 7.3 Prescriber's Letter 12(4): 2005
  8. 8.0 8.1 Dahlof B et al. for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): A multicentre randomised controlled trial. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16154016 Lancet 2005 Sep 10; 366:895-906.
    Staessen JA and Birkenhager WH. Evidence that new antihypertensives are superior to older drugs. Lancet 2005 Sep 10; 366:869-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16153995
  9. 9.0 9.1 Deprecated Reference
  10. Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
  11. Department of Veterans Affairs, VA National Formulary

Database