beta-1 adrenergic receptor; beta-1 adrenoreceptor; beta-1 adrenoceptor (ADRB1, ADRB1R, B1AR)

Function

• beta-adrenergic receptor
• binds epinephrine & norepinephrine with approximately equal affinity
• interacts with GOPC, MAGI3 & DLG4
• homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase

Structure

• the PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 & DLG4 & plays a role in subcellular location of the receptor
• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane
• localized at the plasma membrane
• found in the Golgi upon GOPC overexpression Comparative-biology:
• polymorphism(s) in the gene may confer tendency to fibrosis & response of myocardial tissue to beta-blockers in mice

More general terms

• beta adrenergic receptor

Additional terms

• beta-1 adrenergic receptor agonist
• beta-1 adrenergic receptor antagonist (beta-1 blocker)

Database

• OMIM: https://mirror.omim.org/entry/109630
• OMIM: https://mirror.omim.org/entry/607276
• UniProt: http://www.uniprot.org/uniprot/P08588.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=153