beta adrenergic receptor kinase-1 (ADRBK1, G protein-coupled receptor kinase-2)

Function

• specifically phosphorylates agonist-occupied form of the beta-adrenergic receptors & closely related receptors, probably inducing a desensitization of them
• interacts with GIT1 (putative)
• interacts with, & phosphorylates chemokine-stimulated CCR5

ATP + [beta-adrenergic receptor]
               <-->
ADP + [beta-adrenergic receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 PH domain
• contains 1 protein kinase domain
• contains 1 RGS domain

Expression

expressed in peripheral blood leukocytes

More general terms

• G protein-coupled receptor kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P25098.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:156
• OMIM: https://mirror.omim.org/entry/109635
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=156