Golgi-associated PDZ & coiled-coil motif-containing protein; PDZ protein interacting specifically with TC10; PIST; CFTR-associated ligand, fused in glioblastoma (GOPC, CAL, FIG)
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Function
- intracellular protein trafficking & degradation
- regulation of CFTR chloride currents & acid-induced ACCN3 (putative)
- autophagy
- overexpression results in CFTR intracellular retention & degradation in the lysosomes
- interacts with FZD5, FZD8, GRID2, BECN1, CSPG5, CLCN3, CACNG2, STX6, CFTR, ACCN3, GOLGA3 RHOQ
Structure
homooligomer
Compartment
- cytoplasm Golgi membrane, peripheral membrane
- enriched in synaptosomal & postsynaptic densities (PSD)
- cell bodies & dendrites of Purkinje cells
- localized at the trans-Golgi network (TGN) of spermatids & the medulla of round spermatides
Alternative splicing
named isoforms=3
Expression
ubiquitously expressed
Pathology
- chromosomal aberration involving GOPC gene is found in glioblastoma multiform (GBM)
- homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity