Beclin-1; coiled-coil myosin-like BCL2-interacting protein; protein GT197 (BECN1, GT197)

Function

• role in autophagy
• required for the abcission step in cytokinesis
• may play a role in antiviral host defense
• protects against infection by a neurovirulent strain of sindbis virus
• phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 & BCL2L1 & promotes induction of autophagy
• ubiquitinated
• deubiquitinated by USP10 & USP13, leading to stabilize the PIK3C3/VPS34-containing complexes
• interacts with GOPC & GRID2
• interacts with AMBRA1
• forms a complex with PIK3C3 & PIK3R4 & either UVRAG & KIAA0226/Rubicon, or with ATG14
• UVRAG & ATG14 form mutually exclusive complexes through direct competition for BECN1-binding
  • the complex containing ATG14 up-regulates autophagy
  • the complex containing Rubicon down-regulates autophagy (putative)
• interacts with BCL2 & BCL2L1
• interacts with VMP1
• interacts with PIK3CB (putative)
• interacts with DAPK1
• interacts with human cytomegalovirus/HHV-5 protein TRS1

Structure

belongs to the beclin family

Compartment

• Golgi, trans-Golgi network membrane
• peripheral membrane protein
• interaction with ATG14 promotes translocation to autophagosomes
• expressed in dendrites & cell bodies of cerebellar Purkinje cells (putative)

Expression

ubiquitous

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8678
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8678
• OMIM: https://mirror.omim.org/entry/604378
• UniProt: http://www.uniprot.org/uniprot/Q14457.html