transmembrane protein 49 (vacuole membrane protein 1, TMEM49, TDC1, VMP1, HSPC292)

Function

• stress-induced protein
• when overexpressed, promotes formation of intracellular vacuoles followed by cell death

Structure

belongs to the TMEM49 family

Compartment

• endoplasmic reticulum-Golgi intermediate compartment (putative)
• membrane

Pathology

• role in cytoplasmic vacuolization of acinar cells during early stage of acute pancreatitis

More general terms

• transmembrane 7c protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96GC9.html