tumor protein p53-inducible nuclear protein 1 (p53-dependent damage-inducible nuclear protein 1, p53DINP1, stress-induced protein, TP53INP1, P53DINP1, SIP)

Function

• promotes p53 phosphorylation on Ser-46 & subsequent apoptosis in response to double-strand DNA breaks
• interacts with TP53, HIPK2
• p53-dependent induction by adriamycin, gamma irradiation, H2O2, & at lower levels ultraviolet irradiation

Compartment

• nucleus
• concentrated in PML/POD/ND10 nuclear bodies

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/606185
• UniProt: http://www.uniprot.org/uniprot/Q96A56.html