ubiquitin carboxyl-terminal hydrolase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10 (USP10, KIAA0190)

^[1]^[2]^[3]

Function

protease specific for ubiquitinated proteins
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
- can remove conjugated ubiquitin from target proteins including as p53/TP53, SNX3 & CFTR
acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action & stabilize p53/TP53
following DNA damage, translocates to the nucleus & deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response
does not deubiquitinate MDM2
deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling
phosphorylated by ATM following DNA damage, leading to stablization & translocation it to the nucleus
interacts with G3BP, which may regulate its function
interacts with p53/TP53, SNX3 & CFTR
implicated in learning & memory & in synaptic growth^[2]

a segmental duplication of chromosome 16 involving USP10 is one of the few features distinguishing the human genome from the chimpanzee genome^[3]

↑ UniProt http://www.uniprot.org/uniprot/Q14694.html
↑ ^2.0 ^2.1 Soncini C, Berdo I, Draetta G. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene. 2001 Jun 28;20(29):3869-79. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11439350
↑ ^3.0 ^3.1 Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour- Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15252450