death-associated protein kinase 1; DAP kinase 1 (DAPK1, DAPK)

Function

• Ca+2/calmodulin-dependent serine/threonine kinase
• acts as a positive regulator of apoptosis
• mediator of gamma-interferon induced cell death
• negatively regulated by autophosphorylation on Ser-308

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
• contains 10 ANK repeats
• contains 1 death domain
• contains 1 protein kinase domain

Compartment

• cytoplasm
• colocalizes with the actin filament system

Alternative splicing

named isoforms=2

Expression

• up-regulated following treatment with interferon-gamma

More general terms

• Ca+2/calmodulin-dependent protein kinase (CaM kinase)
• pro apoptotic protein
• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1612
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1612
• OMIM: https://mirror.omim.org/entry/600831
• UniProt: http://www.uniprot.org/uniprot/P53355.html