phosphatidylinositol 3 kinase catalytic subunit beta (PIK3CB)

Function

• phosphorylates Ptdins, Ptdins4P & Ptdins(4,5)P2 with a preference for Ptdins(4,5)P2
• heterodimer of a p110 (catalytic) & a p85 (regulatory) subunit
• carbohydrate metabolism; inositol phosphate metabolism

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
                      <-->
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Structure

• belongs to the PI3/PI4-kinase family
• contains 1 PI3K/PI4K domain

Expression

expressed ubiquitously

More general terms

• PI-3-kinase p110

Database

• UniProt: http://www.uniprot.org/uniprot/P42338.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5291
• OMIM: https://mirror.omim.org/entry/602925
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5291