PI-3-kinase p110

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Introduction

The p110 catalytic subunit of PI-3-kinase is active only when bound through its N-terminal region to the p85 subunit. Binding occurs via a 102 amino acid inter-SH2 region of p85 (2). Substrates: phosphatidylinositol phosphatidylinositol(4)P phosphatidylinositol(4,5)P2

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Component of

References

  1. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846320
  2. Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science. 1995 Apr 7;268(5207):100-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7701328