phosphatidylinositol 3 kinase catalytic subunit delta (PIK3CD)

Function

• 3-phosphorylates cellular phosphoinositide Ptdins(4,5)P2 to produce Ptdins(3,4,5)P3
• heterodimer of a p110 (catalytic) & a p85 (regulatory) subunit
• interacts with ERAS (putative)
• carbohydrate metabolism; inositol phosphate metabolism
• autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
                   <-->
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Structure

• belongs to the PI3/PI4-kinase family
• contains 1 PI3K/PI4K domain

Expression

expressed predominantly in leukocytes

Pharmacology

• leniolisib (Joenja) FDA-approved for PI3K delta syndrome inhibits PI3K delta

More general terms

• PI-3-kinase p110

Database

• UniProt: http://www.uniprot.org/uniprot/O00329.html
• OMIM: https://mirror.omim.org/entry/602839
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5293