phosphatidylinositol 3 kinase catalytic subunit gamma (PI3-kinase p110 subunit gamma, PIK3CG)

Function

• 3-phosphorylates cellular phosphoinositide Ptdins(4,5)P2 to produce Ptdins(3,4,5)P3
• links G-protein coupled receptor activation to the secondary messenger Ptdins(3,4,5)P3 production
• heterodimer of a catalytic subunit PIK3CG & a regulatory PIK3R5a subunit
• activated by both G-alpha & the G-beta-gamma
• carbohydrate metabolism; inositol phosphate metabolism

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
                    <-->
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Structure

• belongs to the PI3/PI4-kinase family
• contains 1 PI3K/PI4K domain

Expression

pancreas, skeletal muscle, liver & heart

More general terms

• PI-3-kinase p110

Database

• UniProt: http://www.uniprot.org/uniprot/P48736.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5294
• OMIM: https://mirror.omim.org/entry/601232
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5294