ubiquitin carboxyl-terminal hydrolase 13; deubiquitinating enzyme 13; isopeptidase T-3; ISOT-3; ubiquitin thiolesterase 13; ubiquitin-specific-processing protease 13 (USP13, ISOT3)
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Function
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
Structure
- belongs to the peptidase C19 family
- contains 2 UBA domains
- contains 1 UBP-type Zn+2 finger
Expression
highly expressed in ovary & testes