activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1, KIAA1736)

Function

• regulates autophagy & development of the nervous system
• involved in autophagy in controlling protein turnover during neuronal development, & in regulating normal cell survival & proliferation (putative)
• interacts with BECN1
• probably forms a complex with BECN1 & PIK3C3 (putative)

Structure

contains 3 WD repeats

Compartment

cytoplasmic vesicle, autophagosome

Alternative splicing

named isoforms=5

More general terms

• WD repeat protein family

Database

• UniProt: http://www.uniprot.org/uniprot/Q9C0C7.html