apoptosis regulator Bcl-2; B-cell CLL/lymphoma-2 (bcl-2) protein (BCL2)

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Function

Structure

Compartment

Alternative splicing

named isoforms=2; alpha; beta

Expression

expressed in a variety of tissues

Pathology

Laboratory

More general terms

Additional terms

References

  1. Hockenbery D et al Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 1990 Nov 22;348(6299):334-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2250705
  2. Martin SJ, Green DR, Cotter TG. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem Sci. 1994 Jan;19(1):26-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8140617
  3. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature. 1994 May 26;369(6478):321-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8183370
  4. Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 1996 Jan;2(1):80-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8564847
  5. 5.0 5.1 Kumar S. ICE-like proteases in apoptosis. Trends Biochem Sci. 1995 May;20(5):198-202. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7610484
  6. Korsmeyer SJ. Regulators of cell death. Trends Genet. 1995 Mar;11(3):101-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7732571
  7. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11165519
  8. 8.0 8.1 Tsujimoto et al. Science 228:1440-3, 1985
  9. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=596
  10. UniProt http://www.uniprot.org/uniprot/P10415.html
  11. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/BCL2ID49.html
  12. NIEHS-SNPs http://egp.gs.washington.edu/data/bcl2/
  13. Wikipedia; Note: Bcl-2 entry Shttp://en.wikipedia.org/wiki/Bcl-2

Database