Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis (BBC3, PUMA)
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Function
- mediator of p53/TP53-dependent & p53/TP53-independent apoptosis
- interacts with MCL1 & BCL2A1 (putative)
- interacts with BCL2 & BCL2L1/BCL-XL
- isoform 3 fails to show any growth-inhibitory or apoptotic activity
- isoform 3 does not interact with BCL2
Structure
belongs to the Bcl-2 family
Compartment
- mitochondria
- localized to the mitochondria in order to induce cytochrome c release
Alternative splicing
named isoforms=4
Expression
- ubiquitously expressed
- induced by DNA damage, glucocorticoid treatment, growth factor deprivation & p53/TP53
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q96PG8.html
- ↑ UniProt http://www.uniprot.org/uniprot/Q9BXH1.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/BBC3ID759ch19q13.html
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27113
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27113
- OMIM: https://mirror.omim.org/entry/605854
- UniProt: http://www.uniprot.org/uniprot/Q96PG8.html
- UniProt: http://www.uniprot.org/uniprot/Q9BXH1.html