Bcl-2-related protein A1; Bcl-2-like protein 5; Bcl2-L-5; protein BFL-1; hemopoietic-specific early response protein; protein GRS (BCL2A1, BCL2L5, BFL1, GRS, HBPA1)

Function

• inhibits apoptosis induced by IL-3 deprivation
• may function in the response of hemopoietic cells to external signals & in maintaining endothelial survival during infection
• interacts directly with BAK1, BID, BMF & BBC3
• interacts directly with BCL2L11/BIM

Structure

belongs to the Bcl-2 family

Compartment

cytoplasm

Expression

• seems to be restricted to the hematopoietic compartment
• expressed in peripheral blood, spleen, & bone marrow > lung, small intestine & testis > other tissues
• also found in vascular smooth muscle cells
• induced by phorbol ester & inflammatory cytokines, such as TNF-alpha, or IL-1-beta, but not by growth factors

Pathology

• found in hematopoietic malignancies

More general terms

• bcl-2 subfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=597
• OMIM: https://mirror.omim.org/entry/601056
• UniProt: http://www.uniprot.org/uniprot/Q16548.html