Bcl-2-modifying factor (BMF)

Function

• role in apoptosis, isoform 1 main initiator (putative)
• interacts with MCL1, BCL2, BCL2L1/BCL-Xl & BCL2L2/BCL-w
• interacts with the myosin V actin motor complex via binding to DLC2

Structure

• belongs to the Bcl-2 family

Alternative splicing

named isoforms=3

Expression

• isoform 1 is mainly expressed in B-lymphoid cells
• isoform 2 & 3 are mainly expressed in B-CLL & normal B-cells

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/606266
• UniProt: http://www.uniprot.org/uniprot/Q96LC9.html