Bcl-2 homologous antagonist/killer; apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7 (BAK1, BAK, BCL2L7, CDN1)
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Function
- promotes cell death & counteracts protection from apoptosis by bcl-2
- inhibits bcl-2 through formation of heterodimers
- counteracts protection from apoptosis by adenovirus homolog E1B 19k protein
- low micromolar levels of Zn+2 inhibit the promotion of apoptosis
- interacts with BCL2A1 (putative)
- forms heterodimers with BCL2, E1B 19k protein, & BCL2L1 isoform Bcl-XL
Structure
- homodimer; formation of the homodimer is Zn+2-dependent
- binding of bcl2 to Bak1 occurs via BH1 domain & BH2 domain
- Bak1 also forms homodimers
- intact BH3 motif is required by BIK, BID, BAK, BAD & BAX for their pro-apoptotic activity & for their interaction with anti-apoptotic members of the Bcl-2 family
- belongs to the Bcl-2 family
Compartment
mitochondrial outer membrane
Expression
- expressed in wide variety of cell types
- highest levels in the heart & skeletal muscle
More general terms
Additional terms
References
- ↑ Farrow SN, White JH, Martinou I, Raven T, Pun KT, Grinham CJ, Martinou JC, Brown R. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature. 1995 Apr 20;374(6524):731-3. Erratum in: Nature 1995 Jun 1;375(6530):431. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7715729
- ↑ Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):733-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7715730
- ↑ Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):736-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7715731
- ↑ Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11165519
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=578
- ↑ UniProt http://www.uniprot.org/uniprot/Q16611.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/bak1/