bax subfamily protein
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Function
- Bax subfamily proteins promote apoptosis.
- monomers are thought to be inactive
- homo-oligomers are thought to promote apoptosis.
- oligomerization & insertion into the outer mitochondrial membrane may release cytochrome c from mitochondria.
More general terms
More specific terms
- Bcl-2 associated protein X (BAX)
- Bcl-2 homologous antagonist/killer 2; apoptosis regulator BAK-2 (BCL2L7P1 BAK2)
- Bcl-2 homologous antagonist/killer; apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7 (BAK1, BAK, BCL2L7, CDN1)
- Bcl-2-related ovarian killer protein; Bcl-2-like protein 9; Bcl2-L-9; Hbok (BOK, BCL2L9)
References
- ↑ Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001 Sep;8(3):705-11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11583631
- ↑ Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11165519