Bcl-2 homologous antagonist/killer 2; apoptosis regulator BAK-2 (BCL2L7P1 BAK2)
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Function
- in the presence of an appropriate stimulus, accelerates apoptosis by binding to, & antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein
- forms heterodimers with Bcl-2, E1B 19k protein, & Bcl-XL
Structure
- intact BH3 domain is required by BIK, BID, BAK, BAD & BAX for their pro-apoptotic activity & for their interaction with anti-apoptotic members of the Bcl-2 family & apoptotic members of the Bcl-2 family
- belongs to the Bcl-2 family
Compartment
membrane (potential)
Expression
- expressed in a wide variety of tissues, with highest levels in the heart & skeletal muscle
Notes
- could be the product of a pseudogene
- deleted from UniProt database Aug 2010
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q13014.html
- ↑ Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):736-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7715731