adenovirus oncoprotein E1b
Jump to navigation
Jump to search
Introduction
The adenovirus E1b gene encodes 2 distinct transforming proteins, 19 & 55 kD proteins, both of which independently cooperate with E1a suppressing apoptosis & thereby permitting transformation by E1a[4]. E1b inhibits apoptosis via binding to & inhibiting transcriptional activity of p53[3].
More general terms
References
- ↑ Wilcock D, Lane DP. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells. Nature. 1991 Jan 31;349(6308):429-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1671528
- ↑ Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995 Mar 10;267(5203):1456-62. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7878464 (apoptosis inhibitor)
- ↑ 3.0 3.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
- ↑ 4.0 4.1 Debbas M, White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 1993 Apr;7(4):546-54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8384580