Bcl-2-interacting killer; apoptosis inducer NBK; BP4; BIP1 (BIK, NBK)

Function

• accelerates apoptosis
• binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity
• does not interact with BAX

Structure

• intact BH3 motif is required by BIK, BID, BAK, BAD & BAX for their pro-apoptotic activity & for their interaction with anti-apoptotic members of the Bcl-2 family

Compartment

• intracytoplasmic membrane
• around the nuclear envelope, & in cytoplasmic membranes

More general terms

• BH3 subfamily protein
• pro apoptotic protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q13323.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=638
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:638
• OMIM: https://mirror.omim.org/entry/603392