BH3 subfamily protein

Function

• Bcl-2 family members promoting apoptosis
• thought to be 'Sentinals of cellular damage' & triggers of apoptosis

Structure

• characterized by containing only the BH3 domain & not BH1, BH2 or BH4
• C terminal hydrophobic domain is thought to facilitate interaction with the endoplasmic reticulum &/or nuclear membrane
• pro-apoptotic BH3 subfamily of proteins is thought to bind to anti-apoptotic bcl-2 subfamily members resulting in an inactive complex

More general terms

• bcl-2 family protein

More specific terms

• activator of apoptosis harakiri; neuronal death protein DP5; BH3-interacting domain-containing protein 3 (HRK, BID3)
• Bcl-2-interacting killer; apoptosis inducer NBK; BP4; BIP1 (BIK, NBK)
• Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death (BCL2L11, BIM)
• Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter (BAD, BBC6, BCL2L8)
• BH3-interacting domain death agonist; p22 BID; BID; contains: BH3-interacting domain death agonist p15; p15 BID; contains: BH3-interacting domain death agonist p13; p13 BID; contains: BH3-interacting domain death agonist p11; p11 BID (BID)
• Noxa
• p53 upregulated modulator of apoptosis (PUMA)