Noxa
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Function
- mediator of p53 induced apoptosis
- Noxa coprecipitates with anti-apoptotic bcl2 family members (bcl-XL, bcl-2, Mcl-1) but not bax
Compartment
- mitochondrial localization dependent on functional BH3 motifs
More general terms
References
- ↑ Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000 May 12;288(5468):1053-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10807576