p53 upregulated modulator of apoptosis (PUMA)
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Function
- mediates p53-associated apoptosis
- binds to bcl-2 & bcl-xL through BH3 domain,
- induces cytochrome c release & programmed cell death
Compartment
Alternative splicing
two forms PUMA-alpha & PUMA-beta
More general terms
References
- ↑ Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11463391
- ↑ Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001 Mar;7(3):683-94. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11463392