mitochondrial 39S ribosomal protein L41 (L41mt, MRP-L41, 39S ribosomal protein L27 homolog, MRP-L27 homolog, BCL2-interacting mitochondrial ribosomal protein L41, proliferation-inducing gene 3 protein, MRPL41, BMRP, PIG3, RPML27)

Function

• component of the mitochondrial 39S ribosomal subunit
• role in apoptosis & cell cycle
• enhances TP53/p53 stability, thus contributing to TP53/p53- induced apoptosis in response to growth-inhibition
• enhances TP53/p53 translocation to mitochondria
• able to arrest cell cycle at G1 phase, possibly by stabilizing CDKN1A & CDKN1B (p27Kip1)
• interacts with BCL2

Structure

belongs to the ribosomal protein L41 family

Compartment

mitochondria

Expression

• present in kidney, liver, thymus, testis > brain, spleen (at protein level)

More general terms

• mitochondrial ribosomal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IXM3.html