frizzled-8; Fz-8; hFz8 (FZD8)

Function

• receptor for Wnt proteins
• most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes
• a second signaling pathway involving PKC & Ca+2 fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase
• both pathways seem to involve interactions with G-proteins
• may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues
• interacts with GOPC
• interacts with RSPO1 & RSPO3
• ryk tyrosine kinase receptor

Structure

• the PDZ-binding motif mediates interaction with GOPC
• Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative)
• FZ domain is involved in binding with Wnt ligands
• belongs to the G-protein coupled receptor Fz/smo family
• contains 1 FZ (frizzled) domain

Compartment

• membrane

Expression

• most abundant in fetal kidney, followed by brain & lung
• in adults, expressed in kidney, heart, pancreas & skeletal muscle

More general terms

• frizzled homolog protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8325
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8325
• OMIM: https://mirror.omim.org/entry/606146
• UniProt: http://www.uniprot.org/uniprot/Q9H461.html