tyrosine-protein kinase RYK (RYK, JTK5A)

Function

• coreceptor along with Frizzled for Wnt ligands
• required for neurite outgrowth induced by Wnt-3a
• required in the activation of T cell factor (TCF) induced by Wnt-1
• binds dishevelled through which it activates canonical Wnt pathway
• interacts with frizzled 8

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family
• contains 1 protein kinase domain
• contains 1 WIF domain

Compartment

membrane (putative)

Alternative splicing

named isoforms=2

Expression

observed in all tissues examined

More general terms

• tyrosine kinase receptor (RTK)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6259
• OMIM: https://mirror.omim.org/entry/600524
• UniProt: http://www.uniprot.org/uniprot/P34925.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6259