frizzled homolog protein

^[1]

Function

receptor for Wnt proteins
most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes
a second signaling pathway involving PKC & Ca+2 fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase
both pathways seem to involve interactions with G-proteins
may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues