secreted frizzled-related protein (sFRP) family
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Function
- inhibitor of Wnt signaling
- may function either by interacting with Wnt preventing binding to frizzled or forming nonfunctional complexes with frizzled
Structure
- in addition to sRFP1-5, other family members include sizzled-1 & sizzled-2 & crescent, homologs of which have not been identified in mammals
Compartment
More general terms
More specific terms
- secreted frizzled-related protein 1; FRP-1; sFRP-1; secreted apoptosis-related protein 2; SARP-2 (SFRP1, FRP, FRP1, SARP2)
- secreted frizzled-related protein 2; FRP-2; sFRP-2; secreted apoptosis-related protein 1; SARP-1 (SFRP2, FRP2, SARP1, FKSG12, UNQ361/PRO697)
- secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; FrzB-1 (FRZB FIZ FRE FRP FRZB1 SFRP3)
- secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE (SFRP4, FRPHE)
- secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; secreted apoptosis-related protein 3; SARP-3 (SFRP5, FRP1B, SARP3)
Additional terms
References
- ↑ Kawano Y & Kypta R Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627-2634, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12775774