secreted frizzled-related protein 2; FRP-2; sFRP-2; secreted apoptosis-related protein 1; SARP-1 (SFRP2, FRP2, SARP1, FKSG12, UNQ361/PRO697)

Function

• soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts
• they have a role in regulating cell growth & differentiation in specific cell types
• SFRP2 may be important for eye retinal development & for myogenesis

Structure

• the FZ domain is involved in binding with Wnt ligands
• belongs to the secreted frizzled-related protein (sFRP) family
• contains 1 FZ (frizzled) domain
• contains 1 NTR domain

Compartment

secreted (putative)

Expression

• expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine & colon
• highest levels in adipose tissue, small intestine & colon

More general terms

• secreted frizzled-related protein (sFRP) family
• apoptosis related protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6423
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6423
• OMIM: https://mirror.omim.org/entry/604157
• UniProt: http://www.uniprot.org/uniprot/Q96HF1.html