secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; secreted apoptosis-related protein 3; SARP-3 (SFRP5, FRP1B, SARP3)

Function

• soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts
• they have a role in regulating cell growth & differentiation in specific cell types
• SFRP5 may be involved in determining the polarity of photoreceptors, & perhaps, other cells in the retina

Structure

• the FZ domain is involved in binding with Wnt ligands
• belongs to the secreted frizzled-related protein (sFRP) family
• contains 1 FZ (frizzled) domain
• contains 1 NTR domain

Compartment

secreted (putative)

Expression

• highly expressed in the retinal pigment epithelium (RPE) & pancreas
• weak expression in heart, liver & muscle

More general terms

• secreted frizzled-related protein (sFRP) family
• apoptosis related protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6425
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6425
• OMIM: https://mirror.omim.org/entry/604158
• UniProt: http://www.uniprot.org/uniprot/Q5T4F7.html