frizzled-1; Fz-1; hFz1; FzE1 (FZD1)

Function

• receptor for Wnt proteins
• most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes
• a second signaling pathway involving PKC & Ca+2 fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase
• both pathways seem to involve interactions with G-proteins
• may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues
• activated by Wnt3A, Wnt3, Wnt1 & to a lesser extent Wnt2,
• not activated by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B
• - binds to LRP1 which leads to repression of canonical wnt signaling

Structure

• Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative)
• FZ domain is involved in binding with Wnt ligands
• belongs to the G-protein coupled receptor Fz/smo family
• contains 1 FZ (frizzled) domain

Compartment

• membrane

Expression

• expressed in adult heart, placenta, lung, kidney, pancreas, prostate, & ovary & in fetal lung & kidney

More general terms

• frizzled homolog protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8321
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8321
• OMIM: https://mirror.omim.org/entry/603408
• UniProt: http://www.uniprot.org/uniprot/Q9UP38.html