wnt1 proto-oncogene protein; int1 proto-oncogene protein; wingless (WNT1, INT1)

Function

• ligand for members of the frizzled family
• probable developmental protein
• may be a signaling molecule important in CNS development
• likely to signal over only few cell diameters
• interacts with PORCN
• interacts with RSPO1, RSPO2 & RSPO3 (putative)
• Wnt1 signaling pathway inhibited by: DKK1, SOST, WIF1

Structure

belongs to the Wnt family

Compartment

• secreted, extracellular space, extracellular matrix

More general terms

• wnt proto-oncogene protein or int proto-oncogene protein
• secreted protein

Additional terms

• Wnt-1 signalling

Database

• UniProt: http://www.uniprot.org/uniprot/P04628.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7471
• OMIM: https://mirror.omim.org/entry/164820
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7471