sclerostin (SOST)

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Function

Structure

  • belongs to the sclerostin family
  • contains 1 CTCK domain (C-terminal cystine knot-like domain)

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

Pathology

Pharmacology

Physiology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q9BQB4.html
  2. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SOST
  3. 3.0 3.1 3.2 McClung MR et al Romosozumab in Postmenopausal Women with Low Bone Mineral Density. N Engl J Med. Jan 1, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24382002 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1305224
    Becker CB Sclerostin Inhibition for Osteoporosis - A New Approach. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24382003 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMe1315500
  4. 4.0 4.1 4.2 Misra M Which Exercise Is Best for Bone Health? Medscape. Nov 14, 2022 https://www.medscape.com/viewarticle/983792

Database