R-spondin-2 (roof plate-specific spondin-2, hRspo2, RSPO2)

Function

• activator of the beta-catenin signaling cascade
• TCF-dependent gene activation
• role in Wnt/beta-catenin-dependent pathway
  • via a direct interaction with Wnt proteins
• role in Wnt-independent beta catenin pathway
• acts as a ligand for frizzled FZD8 & LRP6
• interacts with WNT1
• binds heparin
• FU repeat required for activation & stabilization of beta-catenin
• upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization
• efficacy in a model of chemotherapy-induced intestinal mucositis

Compartment

secreted

Alternative splicing

named isoforms=3

More general terms

• R-spondin (roof plate-specific spondin)
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UXX9.html