R-spondin-3 (roof plate-specific spondin-3, hRspo3, thrombospondin type-1 domain-containing protein 2, protein with TSP type-1 repeat, hPWTSR, RSPO3, PWTSR, THSD2)
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Function
- activator of the beta-catenin signaling cascade
- TCF-dependent gene activation
- role in Wnt/beta-catenin-dependent pathway
- via a direct interaction with Wnt proteins
- role in Wnt-independent beta catenin pathway
- acts as a ligand for frizzled FZD8 & LRP6
- may negatively regulate the TGF-beta pathway
- interacts with the extracelular domain of FZD8 & LRP6 (does NOT form a ternary complex)
- interacts with WNT1
- binds heparin
- FU repeats required for activation & stabilization of beta-catenin
- upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization
- efficacy in a model of chemotherapy-induced intestinal mucositis
Compartment
Alternative splicing
named isoforms=2
Expression
- ubiquitous
- expressed at higher level in placenta, small intestine, fetal thymus, lymph node
More general terms
- R-spondin (roof plate-specific spondin)
- secreted protein
- glycoprotein
- thrombospondin type-1 domain-containing protein (THSD)