protein-cysteine N-palmitoyltransferase porcupine (protein MG61, PORCN, MG61, PORC, PPN)

Function

• modulates the processing of Wnt proteins
• probable protein-cysteine N-palmitoyltransferase that palmitoylates WNT family members
• interacts with WNT1, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A & WNT7B (putative)

Structure

• belongs to the membrane-bound acyltransferase family, porcupine subfamily

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=4

Expression

• isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle & testis
• isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis
• isoforms 2 & 3 are expressed in substantia negra, spinal cord, heart & lung

Pathology

• variants in PORCN at Xp11.23 associated with focal dermal hypoplasia

More general terms

• S-palmitoyl transferase
• transmembrane 8 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H237.html